What is most rare hair and eye color combination?

The combination of red hair and blue eyes is the rarest hair and eye color combination in the world. Only around 1% of the world's population has natural red hair, and only around 17% of people with red hair have blue eyes. The gene mutations that cause red hair and blue eyes are both recessive, which means that they are inherited from both parents. The rarity of this combination is due to the fact that both mutations must occur in the same individual for the trait to be expressed. This combination is more common in people of Celtic or Northern European ancestry, but can occur in other populations as well. The unique combination is often considered striking and eye-catching, and many celebrities such as Julianne Moore and Karen Gillan have made it famous.